Deficits in mesolimbic reward pathway underlie social interaction impairments in children with autism
نویسندگان
چکیده
منابع مشابه
Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits
Ventral tegmental area (VTA) activity is critical for reward/reinforcement and is tightly modulated by the laterodorsal tegmentum (LDT). In utero exposure to glucocorticoids (iuGC) triggers prominent motivation deficits but nothing is known about the impact of this exposure in the LDT-VTA circuit. We show that iuGC-rats have long-lasting changes in cholinergic markers in the LDT, together with ...
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Objective: The present study has been carried out to compare the social competence in two groups of students with Autism Disorder (AD) and Learning Disorders (LD). Methods: This research was a kind of descriptive research with 2 comparative groups. 90 learning and Autistic disorder students aged 10 to 13 years (45 LD & 45 AD) were selected randomly as a statistical sample. For the assessment...
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An Augmented Knight’s Castle (AKC) play set was adapted so that children with autism can configure programmable elements. This is compared with a non-configurable AKC. When the system is configurable, and when it is switched on, less solitary play and more cooperative play occur. Digital toys and their configurability are key factors in design for children with autism, allowing greater individu...
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ژورنال
عنوان ژورنال: Brain
سال: 2018
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awy191